SML1851

RI(dl)-2

≥98% (HPLC)

• Synonym(e): N-Ethyl-4-(pyrrolo[1,2-a]quinoxalin-4-yl)aniline
• Empirische Formel (Hill-System): C₁₉H₁₇N₃ · xC₂HF₃O₂
• CAS-Nummer: 1902146-75-1
• Molekulargewicht: 287.36 (free base basis)
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: , light orange to dark red
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: CCNC1=CC=C(C2=NC3=C(N4C2=CC=C4)C=CC=C3)C=C1.FC(F)(C(O)=O)F

Beschreibung

Biochem./physiol. Wirkung

RI(dl)-2 is a cell-permeable pyrroloquinoxaline derivative that selectively inhibits Rad51-mediated D-loop formation (IC₅₀ = 11.1 μM) without affecting its ssDNA-binding activity (IC₅₀ >100 μM). RI(dl)-2 is shown to inhibit DSBs-induced cellular homologous recombination (HR) activity (IC₅₀ = 3.0 μM by HEK293-based DR-GFP reporter assay) by stabilizing nucleoprotein filaments in a nonfunctional state without affecting DNA damage-induced RAD51 nuclear loci formation or stimulating single-strand annealing (SSA) activity.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable