SML1672

JT010

≥98% (HPLC)

• Synonym(e): 2-Chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl)-acetamide
• Empirische Formel (Hill-System): C₁₆H₁₉ClN₂O₃S
• CAS-Nummer: 917562-33-5
• Molekulargewicht: 354.85
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329826007

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 10 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: O=C(N(C1=NC(C2=CC=C(OC)C=C2)=CS1)CCCOC)CCl

Beschreibung

Biochem./physiol. Wirkung

JT010 is a non-cytotoxic and highly stable (>90% remains after 2 h in 1 mM DTT or 2-mercaptoethanol) chloroacetamido warhead-carrying thiazole derivative that acts as a potent and TRPA1-selective channel activator via covalent modification of TRPA1 active site Cys621. JT0101 stimulates calcium influx in TRPA1-transfected HEK293 cells in a dose-dependent manner (EC₅₀ = 650 pM) with excellent selectivity over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC₅₀ >1 μM).

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable