SML1654

R-Ketorolac

≥95% (HPLC)

• Synonym(e): (+)-Ketorolac, (1R)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid;, (R)-(+)-ketorolac, (R)-Ketorolac
• Empirische Formel (Hill-System): C₁₅H₁₃NO₃
• CAS-Nummer: 66635-93-6
• Molekulargewicht: 255.27
• MDL-Nummer: MFCD00871492
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825993

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D +162 to +178°, c = 1 in methanol
• Farbe: white to beige
• Löslichkeit: DMSO: 25 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: O=C(O)[C@H]1C2=CC=C(C(C3=CC=CC=C3)=O)N2CC1
• InChI: 1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)/t11-/m1/s1
• InChIKey: OZWKMVRBQXNZKK-LLVKDONJSA-N

Beschreibung

Biochem./physiol. Wirkung

Ketorolac ((rac)-5-benzoyl-1,2-3H-pyrrolo[1,2a] pyrrole1-carboxylic acid) is a non-steroidal anti-inflammatory drug (NSAID). It is used as a racemic mixture that contains a 1:1 ratio of the R(+) and S(−) stereoisomers. It is broadly used off-label as a parenteral analgesic in children. Ketorolac serves as a non-narcotic analgesic. It prevents the synthesis of prostaglandins, peripheral to the central nervous system.

R-Ketorolac is potent and selective Rho-family GTPases Cdc42 (cell division control protein 42) and Rac1 (Ras-related C3 botulinum toxin substrate 1) allosteric inhibitor that modulates downstream GTPase-dependent physiologic responses critical to tumor metastasis. R-ketorolac significantly inhibits ovarian cancer cell adhesion, migration, and invasion.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315 - H319 - H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable