SML1567

MCB-613

≥98% (HPLC)

• Synonym(e): 4-Ethyl-2,6-bis(pyridin-3-ylmethylene)cyclohexanone
• Empirische Formel (Hill-System): C₂₀H₂₀N₂O
• CAS-Nummer: 296792-62-6
• Molekulargewicht: 304.39
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 5 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C

Beschreibung

Allgemeine Beschreibung

MCB-613 (4-Ethyl-2,6-bis-pyridin-3-ylmethylene-cyclohexanone) belongs to the chalcone class of compounds. It is an anti-neoplastic compound.

Anwendung

MCB-613 has been used to study the molecular mechanism of MCB-613-induced cell death.

Biochem./physiol. Wirkung

MCB-613 is a pan-Steroid Receptor Coactivator (SRC) stimulator. There are three steroid receptor coactivators (SRC) that interact with transcription factors and whose overexpression is assciated with a number of cancers, particularly breast cancer. MCB-613 overstimulates SRC activity in cancer cells resulting in excessive generation of reactive oxygen species (ROS), leading to cell stress and death by a process called paraptosis. MCB-613 is a cytotoxic molecule which can kill various human cancer cell lines, like HepG2 (liver), PC-3 (prostate) and MCF-7 (breast) cells.

MCB-613 is capable of inducing the transcriptional activity of steroid receptor coactivators (SRCs).

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable