SML0961

Kobe0065

≥98% (HPLC)

• Synonym(e): N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-hydrazinecarbothioamide
• Empirische Formel (Hill-System): C₁₅H₁₁ClF₃N₅O₄S
• CAS-Nummer: 436133-68-5
• Molekulargewicht: 449.79
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 15 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: FC(F)(F)c1cc(c(c(c1)[N+](=O)[O-])NNC(=S)Nc2cc(c(cc2)C)Cl)[N+](=O)[O-]
• InChI: 1S/C15H11ClF3N5O4S/c1-7-2-3-9(6-10(7)16)20-14(29)22-21-13-11(23(25)26)4-8(15(17,18)19)5-12(13)24(27)28/h2-6,21H,1H3,(H2,20,22,29)
• InChIKey: KSJVAYBCXSURMQ-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Kobe0065 binds to Ras-GTP, blocking interactions with Raf kinase. Kobe0065 inhibits anchorage-dependent and -independent growth, blocks MEK/ERK activity and induces apoptosis in H-rasG12V transformed NIH3T3 cells. The compound Kobe0065 also inhibts tumor growth in SW480 colon cancer cell xenografts.

Kobe0065 is an inhibitor of Ras activity.

Leistungsmerkmale und Vorteile

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Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable