SML0897

ALX 5407 hydrochloride

≥98% (HPLC)

• Synonym(e): ALX-5407 hydrochloride, N-[3-(4′-Fluorophenyl)-3-(4′-phenylphenoxy)propyl]sarcosine hydrochloride, NFPS hydrochloride
• Empirische Formel (Hill-System): C₂₄H₂₄NO₃F·HCl
• CAS-Nummer: 200006-08-2
• Molekulargewicht: 429.91
• MDL-Nummer: MFCD09971056
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825613
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: DMSO: 5 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C
• SMILES String: Cl.CN(CC[C@@H](Oc1ccc(cc1)-c2ccccc2)c3ccc(F)cc3)CC(O)=O
• InChI: 1S/C24H24FNO3.ClH/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18;/h2-14,23H,15-17H2,1H3,(H,27,28);1H/t23-;/m1./s1
• InChIKey: RPDGSZCYSJWQEE-GNAFDRTKSA-N

Beschreibung

Anwendung

ALX 5407 hydrochloride has been used as a glycine transporter (GlyT1) inhibitor to test its effect on inhibitory postsynaptic current and N-methyl-D-aspartate receptor (NMDA)-mediated excitatory postsynaptic currents (EPSCs). It has also been used as a GlyT1 inhibitor to treat developmentally diminished NMDA receptor (Grin1D481N) mice to test its effect on the glycine site function.

Biochem./physiol. Wirkung

ALX-5407 hydrochloride (NFPS hydrochloride) is a selective irreversible inhibitor of the glycine transporter GlyT1 with IC₅₀ values of 3 nM for GlyT1 compared to 100 μM for GlyT2. ALX-5407 hydrochloride showed no activity at the inhibitory glycine receptor or glycine site of the NMDA receptor (IC₅₀ > 100 mM).

Leistungsmerkmale und Vorteile

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Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H302,H410
• P-Sätze: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable