SML0345

A 887826

≥98% (HPLC)

• Synonym(e): 5-(4-butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl]-3-pyridinecarboxamide
• Empirische Formel (Hill-System): C₂₆H₂₉ClN₄O₃
• CAS-Nummer: 1266212-81-0
• Molekulargewicht: 480.99
• MDL-Nummer: MFCD20926345
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825349
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: ≥5 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: CCCCOc1ccc(cc1Cl)-c2cncc(c2)C(=O)NCc3cccnc3N4CCOCC4
• InChI: 1S/C26H29ClN4O3/c1-2-3-11-34-24-7-6-19(15-23(24)27)21-14-22(17-28-16-21)26(32)30-18-20-5-4-8-29-25(20)31-9-12-33-13-10-31/h4-8,14-17H,2-3,9-13,18H2,1H3,(H,30,32)
• InChIKey: JPJGFWKHSMUKFO-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

A-887826 is Nav1.8 channel blocker (IC₅₀ = 11 nM) that blocks TTX-resistant sodium currents in rat dorsal root ganglion in a voltage dependent fashion. Oral administration of A-887826 to rats significantly attenuated tactile allodynia in a neuropathic pain model.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P264 - P270 - P301 + P310 - P405 - P501
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable