SML0324

JW67

≥98% (HPLC)

• Synonym(e): Trispiro[3H-indole-3,2′-[1,3]dioxane-5′,5′′-[1,3]dioxane-2′′,3′′′-[3H]indole]-2,2′′′(1H,1′′′H)-dione (9CI)
• Empirische Formel (Hill-System): C₂₁H₁₈N₂O₆
• CAS-Nummer: 442644-28-2
• Molekulargewicht: 394.38
• MDL-Nummer: MFCD03036757
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825329
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: >5 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: O=C1Nc2ccccc2C13OCC4(CO3)COC5(OC4)C(=O)Nc6ccccc56
• InChI: 1S/C21H18N2O6/c24-17-20(13-5-1-3-7-15(13)22-17)26-9-19(10-27-20)11-28-21(29-12-19)14-6-2-4-8-16(14)23-18(21)25/h1-8H,9-12H2,(H,22,24)(H,23,25)
• InChIKey: BTXRSHKJNDFHGA-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

JW67 is an efficient and specific inhibitor of the canonical Wnt signaling in vitro and in vivo. It appears that JW67 affects the multiprotein complex consisting of β-catenin/GSK-3b/AXIN/APC/CK1 that controls the degradation of β-catenin. JW67 reduces growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S phase.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P301 + P310
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable