SML0278

SR 48692

≥98% (HPLC)

• Synonym(e): 2-[[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylic acid, Meclinertant
• Empirische Formel (Hill-System): C₃₂H₃₁ClN₄O₅
• CAS-Nummer: 146362-70-1
• Molekulargewicht: 587.07
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825286
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: ≥2 mg/mL (warmed)
• Lagertemp.: −20°C
• SMILES String: COc1cccc(OC)c1-c2cc(nn2-c3ccnc4cc(Cl)ccc34)C(=O)NC5(C6CC7CC(C6)CC5C7)C(O)=O
• InChI: 1S/C32H31ClN4O5/c1-41-27-4-3-5-28(42-2)29(27)26-16-24(36-37(26)25-8-9-34-23-15-21(33)6-7-22(23)25)30(38)35-32(31(39)40)19-11-17-10-18(13-19)14-20(32)12-17/h3-9,15-20H,10-14H2,1-2H3,(H,35,38)(H,39,40)
• InChIKey: DYLJVOXRWLXDIG-UHFFFAOYSA-N
• Angaben zum Gen: human ... NTSR1(4923)

Beschreibung

Anwendung

SR 48692 has been used as a neurotensin high-affinity receptor 1 (NTSR1) antagonist:

• to explore the function of NTSR1 in glioblastoma (GBM) cells
• to determine the roles of neurotensin (NT) in the regulation of bile acid (BA) uptake, in vivo
• to explore the involvement of NTSR1 versus NTSR2 in mice

Biochem./physiol. Wirkung

SR 48692 is a high affinity, orally bioavailable and selective nonpeptide NT1 neurotensin receptor antagonist that antagonizes neurotensin-induced calcium mobilization with a pA2 of 8.13 in HT-29 human colon carcinoma cell line, and blocks the ability of neurotensin to increase GABA levels in the prefrontal cortex.

Leistungsmerkmale und Vorteile

This compound is featured on the Neurotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable