SML0059

BLT-1

≥98% (HPLC)

• Synonym(e): 2-Hexyl-1-cyclopentanone thiosemicarbazone, 33M20, BLT1, Block lipid transport-1, MIT 9952-53
• Empirische Formel (Hill-System): C₁₂H₂₃N₃S
• CAS-Nummer: 321673-30-7
• Molekulargewicht: 241.40
• MDL-Nummer: MFCD00571007
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 329825125
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to tan
• Löslichkeit: DMSO: ≥13 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: CCCCCCC1CCC\C1=N/NC(N)=S
• InChI: 1S/C12H23N3S/c1-2-3-4-5-7-10-8-6-9-11(10)14-15-12(13)16/h10H,2-9H2,1H3,(H3,13,15,16)/b14-11+
• InChIKey: OWGUSBISUVLUJF-SDNWHVSQSA-N

Beschreibung

Anwendung

BLT-1 (Block lipid transport-1) has been used as an inhibitor of the SR-BI (scavenger receptor, class B, type I) mediated lipid transfer to determine if miR-223-3p export from polymorphonuclear neutrophils (PMNs) to high-density lipoproteins (HDLs) is dependent on SR-BI-mediated lipid flux. It has also been used as a SR-BI inhibitor to study the effect of HDL on osteocalcin (OCN) expression in monocyte cell lines through SR-B1.

BLT-1 may be used to study cell signaling pathways that have role in cholesterol influx and efflux.

Biochem./physiol. Wirkung

Block lipid transport-1 (BLT-1) is a specific inhibitor of the SR-BI (Scavenger receptor, class B, type I) mediated lipid transfer. The compound inhibits both cellular selective lipid uptake of HDL cholesteryl ether and efflux of cellular cholesterol to HDL.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable