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Merck

SCP0195

Sigma-Aldrich

MOG Protein 35-55, MOG Peptide Fragment human

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About This Item

Empirische Formel (Hill-System):
C120H179N35O28S1
Molekulargewicht:
2591.99
UNSPSC-Code:
12352202
NACRES:
NA.32

Assay

≥95% (HPLC)

Form

lyophilized

Zusammensetzung

Peptide Content, ≥75%

Lagerbedingungen

protect from light

Lagertemp.

−20°C

Amino Acid Sequence

Met-Glu-Val-Gly-Trp-Tyr-Arg-Pro-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys

Allgemeine Beschreibung

Myelin oligodendrocyte glycoprotein (MOG) is widely expressed at the extracellular surface of myelin sheaths and oligodendrocytes in the central nervous system. The MOG gene is mapped to human chromosome 6p22.1.

Anwendung

MOG Protein 35-55 is used as an antigen/immunogen to induce anti-MOG antibodies to induce experimental diseases such as experimental autoimmune encephalomyelitis (EAE) for study.

Biochem./physiol. Wirkung

Myelin oligodendrocyte glycoprotein (MOG) is believed to function as an adhesion protein that support myelination of nerves. MOG is studied to understand the mechanisms of diseases such as adrenoleukodystrophy, vanishing white matter disease, multiple sclerosis (MS) and Rubella-induced mental retardation.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Die Dokumentenbibliothek aufrufen

Huifen Huang et al.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 29(5), 535-545 (2020-05-28)
Multiple sclerosis (MS) is an autoimmune disease characterized by a loss of myelin, limb disabilities and dysregulation of gene expression. Unfortunately, there still is no treatment to cure MS. To explore a novel way to treat MS using currently available
Antibodies to myelin oligodendrocyte glycoprotein in idiopathic optic neuritis.
Nakajima H, et al.
BMJ Open, 5(4), e007766-e007766 (2015)
Immune modulation by a tolerogenic myelin oligodendrocyte glycoprotein (MOG) 10?60 containing fusion protein in the marmoset experimental autoimmune encephalomyelitis model.
Kap YS, et al.
Clinical and Experimental Immunology, 180(1), 28-39 (2015)
The discoidin domain receptor 1 as a novel susceptibility gene for schizophrenia.
Roig B, et al.
Molecular Psychiatry, 12(9), 833-833 (2007)

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