SBVT04
SB-MRP1-Sf9
membrane preparation for Vesicular Transport Assays, recombinant, expressed in baculovirus infected Sf9 cells
Synonym(e):
ABCC1, MRP1, MRP1 humanv membrnae vesicles, Multidrug resistance-associated protein 1
About This Item
Empfohlene Produkte
Rekombinant
expressed in baculovirus infected Sf9 cells
Form
liquid
Konzentration
5 mg/mL
Farbe
off-white
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Lagertemp.
−70°C
Angaben zum Gen
human ... ABCC1(4363)
Allgemeine Beschreibung
Anwendung
The standard vesicular transport assay is an inhibitory assay performed with cold test articles. This assay provides information on any interaction between the ABC transporter and the test article. The transport of the reporter substrate is measured in the presence of the test article (typically in 7 concentrations) and IC50 is defined as the concentration inhibiting the transport of the reporter substrate by 50%.
Should radiolabeled form of the investigated compound or adequate analytical methods (LC/MS, HPLC) be available, the vesicular transport assay may be performed in a direct format without the reporter substrate and may identify substrate nature of the test article. The vesicular transport substrate assay is a low throughput assay. It is suitable for low permeability test compounds as high permeability compounds may escape from the vesicles through the lipid bilayer.
PREDIVEZ vesicular transport kit is sold separately. This transporter membrane vesicle assay requires the PREDIVEZ vesicular transport kit and corresponding control membrane below:
SB PREDIVEZ Reagent Kit for MRP1 part number SBPVR2-9RXN and corresponding control membrane SB-beta-gal-Sf9-CTRL part number SBCT03-1EA
Physikalische Form
Rechtliche Hinweise
Ähnliches Produkt
Lagerklassenschlüssel
12 - Non Combustible Liquids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
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