SAB5701817

Anti-Phospho-PLN-S16/T17 antibody produced in rabbit

• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: liquid
• Speziesreaktivität: mouse, human
• Konzentration: 0.84 mg/mL
• Methode(n): western blot: 1:500-1:2000
• UniProt-Hinterlegungsnummer: P26678
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: phosphorylation (pSer16/pThr17)
• Angaben zum Gen: human ... PLN(5350)

Beschreibung

Allgemeine Beschreibung

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.

Immunogen

A synthetic phosphorylated peptide around of human Phospho-PLN-S16/T17.

Physikalische Form

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable