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Key Documents

SAB5200103

Sigma-Aldrich

Anti-SLC12A1 antibody produced in rabbit

1 mg/mL, affinity isolated antibody

Synonym(e):

Anti-NKCC2, Anti-Slc12a1

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous glycerol solution

Mol-Gew.

antigen predicted mol wt 160 kDa

Speziesreaktivität

rat, mouse, human

Konzentration

1 mg/mL

Methode(n)

western blot: suitable

NCBI-Hinterlegungsnummer

NP_062007

UniProt-Hinterlegungsnummer

Q13621

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

rat ... Slc12a1(25065)

Allgemeine Beschreibung

Solute carrier family 12 member 1 (SLC12A1) is a Na+-K+-Cl- transporter and it is expressed in the thick ascending loop of kidneys in rats. The gene ID of the protein is 25065.

Spezifität

Detects ~160 kDa.

Immunogen

AA109 to 129 of the rat sequence

Biochem./physiol. Wirkung

Solute carrier family 12 member 1 (SLC12A1) functions in water reabsorption in the kidneys.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

PBS, 50% glycerol, and 0.09% sodium azide

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Kazuko Itoh et al.
Biochemical and biophysical research communications, 453(3), 356-361 (2014-09-30)
Sodium reabsorption via Na-K-2Cl cotransporter 2 (NKCC2) in the thick ascending limbs has a major role for medullary osmotic gradient and subsequent water reabsorption in the collecting ducts. We investigated intrarenal localization of three isoforms of NKCC2 mRNA expressions and
Gustavo R Ares et al.
Hypertension (Dallas, Tex. : 1979), 60(6), 1464-1470 (2012-10-31)
Salt-sensitive hypertension involves a renal defect preventing the kidney from eliminating excess NaCl. The thick ascending limb of Henle loop reabsorbs ≈ 30% of filtered NaCl via the apical Na-K-2Cl cotransporter (NKCC2). Higher NKCC2 activity and Cl reabsorption have been
Yanting Chen et al.
Frontiers in physiology, 12, 642274-642274 (2021-04-20)
Emerging evidence is showing that apelin plays an important role in regulating salt and water balance by counteracting the antidiuretic action of vasopressin (AVP). However, the underlying mechanism remains unknown. Here, we hypothesized that (pro) renin receptor (PRR)/soluble prorenin receptor
Aurélie Edwards et al.
American journal of physiology. Renal physiology, 307(2), F137-F146 (2014-05-23)
This study aims to understand the extent to which modulation of the Na(+)-K(+)-2Cl(-) cotransporter NKCC2 differential splicing affects NaCl delivery to the macula densa. NaCl absorption by the thick ascending limb and macula densa cells is mediated by apical NKCC2.

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