SAB4702104

Monoclonal Anti-CD271, purified produced in mouse

• Synonym(e): NGFR, TNFRSF16, p75NGFR, p75NTR
• UNSPSC-Code: 12352203

Eigenschaften

• Konjugat: unconjugated
• Qualitätsniveau: 100
• Antikörper-Produkttyp: primary antibodies
• Klon: NGFR5, monoclonal
• Form: buffered aqueous solution
• Speziesreaktivität: human, ( Non-human primates), ( Rabbit), ( Cat)
• Konzentration: 1 mg/ml
• Methode(n): flow cytometry: suitable; immunocytochemistry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• Isotyp: IgG1
• UniProt-Hinterlegungsnummer: P08138
• Lagertemp.: 2-8°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... NGFR(4804)

Beschreibung

Allgemeine Beschreibung

CD271 / NGFR, also known as p75NGFR or p75NTR, is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells.

Spezifität

The mouse monoclonal antibody NGFR5 (originally C34C) recognizes an epitope within ammino acids 1 - 160 of CD271/NGFR, a 75 kDa transmembrane glycoprotein of the TNFR superfamily.

Immunogen

Purified CD271 protein isolated from human melanoma cell line A875

Physikalische Form

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Angaben zur Herstellung

Purified by protein-A affinity chromatography.

Lagerung und Haltbarkeit

Store at 2-8°C. Do not freeze.

Sonstige Hinweise

The antibody solution should be gently mixed before use.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable