SAB4702062

Monoclonal Anti-HLA-E purified produced in mouse

• Synonym(e): HLA class I histocompatibility antigen, MHC class I antigen E, alpha chain E
• UNSPSC-Code: 12352203

Eigenschaften

• Konjugat: unconjugated
• Qualitätsniveau: 100
• Antikörper-Produkttyp: primary antibodies
• Klon: MEM-E/02, monoclonal
• Form: buffered aqueous solution
• Speziesreaktivität: ( Non-human primates), human
• Konzentration: 1 mg/ml
• Methode(n): immunohistochemistry: suitable; western blot: suitable
• Isotyp: IgG1
• UniProt-Hinterlegungsnummer: P13747
• Lagertemp.: 2-8°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... HLA-E(3133)

Beschreibung

Allgemeine Beschreibung

HLA-E (human leukocyte antigen E) is a non-classical MHC I antigen, which is important for dialogue with NK cells and their regulation through interaction with CD94/NKG2 receptor. Like other MHC I molecules, transmembrane HLA-E molecule (45 kDa) associates with beta2 microglobulin. Unlike HLA-G, expression of HLA-E molecules is not so restricted, but it has been detected at least at mRNA level in virtually all cells and tissues examined. In peripheral blood, HLA-E protein is expressed at least in all mononuclear cells, but in different quantity (B cells and monocytes more than T cells and NK cells).

Spezifität

The antibody MEM-E/02 specifically reacts with an extracellular epitope on denaturated heavy chain of human HLA-E. HLA-E belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of all human cell types.

Immunogen

Recombinant human HLA-E denaturated heavy chain.

Physikalische Form

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Angaben zur Herstellung

Purified by protein-A affinity chromatography.

Lagerung und Haltbarkeit

Store at 2-8°C. Do not freeze.

Sonstige Hinweise

The antibody solution should be gently mixed before use.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable