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Key Documents

SAB4700276

Sigma-Aldrich

Monoclonal Anti-CD16 antibody produced in mouse

clone MEM-154, purified immunoglobulin, buffered aqueous solution

Synonym(e):

Anti-FCGR3A, Anti-FcγRIII

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

mouse

Konjugat

unconjugated

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

MEM-154, monoclonal

Form

buffered aqueous solution

Speziesreaktivität

human

Konzentration

1 mg/mL

Methode(n)

flow cytometry: suitable

Isotyp

IgG1

NCBI-Hinterlegungsnummer

NM_000569.6

UniProt-Hinterlegungsnummer

P08637

Versandbedingung

wet ice

Lagertemp.

2-8°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... FCGR3A(2214)

Allgemeine Beschreibung

The antibody MEM-154 reacts with the epitope on CD16 antigen that residing in proximity to FG loop (probably BC or C′E loop). CD16 is a low affinity receptor for aggregated IgG (FcgammaRIII antigen). The antibody MEM-154 reacts with CD16+ granulocytes.

Immunogen

Human granulocytes

Anwendung

The reagent is designed for Flow Cytometry analysis of human blood cells using 5-10 μg/mL of sample.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Solution in Tris buffered saline, pH 8.0, with 15 mM sodium azide.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Giovanni F Torelli et al.
Haematologica, 99(7), 1248-1254 (2014-03-25)
In this study, we aimed to investigate the pathways of recognition of acute lymphoblastic leukemia blasts by natural killer cells and to verify whether differences in natural killer cell activating receptor ligand expression among groups defined by age of patients
Eri Shimura et al.
Biochemical and biophysical research communications, 453(1), 1-6 (2014-09-11)
IL-17RA is a shared receptor subunit for several cytokines of the IL-17 family, including IL-17A, IL-17C, IL-17E (also called IL-25) and IL-17F. It has been shown that mice deficient in IL-17RA are more susceptible to sepsis than wild-type mice, suggesting
Megan M Tu et al.
Cancer research, 74(14), 3684-3694 (2014-05-08)
According to the missing-self hypothesis, natural killer (NK) cells survey for target cells that lack MHC-I molecules. The Ly49 receptor family recognizes loss of MHC-I and is critical for educating NK cells, conferring the ability to eliminate transformed or infected
Britnie R James et al.
Cancer immunology, immunotherapy : CII, 63(11), 1213-1227 (2014-08-22)
Tumor progression occurs through the modulation of a number of physiological parameters, including the development of immunosuppressive mechanisms to prevent immune detection and response. Among these immune evasion mechanisms, the mobilization of myeloid-derived suppressor cells (MDSC) is a major contributor
Allen Y Chung et al.
Cancer research, 74(19), 5377-5385 (2014-09-18)
Immune dysregulation drives the pathogenesis of chronic inflammatory, autoimmune, and dysplastic disorders. While often intended to address localized pathology, most immune modulatory therapies are administered systemically and carry inherent risk of multiorgan toxicities. Here, we demonstrate, in a murine model
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