SAB4504567

Anti-phospho-VEGFR2 (pTyr¹¹⁷⁵) antibody produced in rabbit

affinity isolated antibody

• Synonym(e): Anti-CD309, Anti-FLK1, Anti-VEGFR, Anti-VEGFR2
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 151 kDa
• Speziesreaktivität: human, rat, mouse
• Konzentration: ~1 mg/mL
• Methode(n): ELISA: 1:10000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI-Hinterlegungsnummer: P35968
• UniProt-Hinterlegungsnummer: P35968
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: phosphorylation (pTyr1175)
• Angaben zum Gen: human ... KDR(3791)

Beschreibung

Allgemeine Beschreibung

The vascular endothelial growth factor receptor-2 (VEGFR-2) is also called as kinase insert domain containing receptor (KDR). There are seven immunoglobulin-like (Ig-like) domains at the extracellular region (EC) of VEGFR-2. This gene is mapped to human chromosome 4q12.

Immunogen

The antiserum was produced against synthesized peptide derived from human VEGFR2 around the phosphorylation site of Tyr1175.

Immunogen Range: 1141-1190

Anwendung

Anti-phospho-VEGFR2 (pTyr1175) antibody has been used in immunoblotting.

Biochem./physiol. Wirkung

The immunoglobulin-like (Ig-like) domains of the vascular endothelial growth factor receptor-2 (VEGFR-2) are essential for specific ligand binding and receptor dimerization. It helps to activate multiple signaling cascades. VEGF-KDR participates in angiogenesis. VEGFR2 is involved in progression of several cancers like gliomas, malignant peripheral nerve sheath tumors, triple-negative breast cancer (TNBC) and gastrointestinal stromal tumors (GISTs).

Leistungsmerkmale und Vorteile

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Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable