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Key Documents

SAB4503787

Sigma-Aldrich

Anti-phospho-Tyrosine Hydroxylase (pSer19) antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

100

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 58 kDa

Speziesreaktivität

mouse, rat, human

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

P07101

UniProt-Hinterlegungsnummer

P07101

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

phosphorylation (pSer19)

Angaben zum Gen

human ... TH(7054)

Allgemeine Beschreibung

Th (tyrosine hydroxylase) is a homotetramer that has regulatory, catalytic and tetramerization domains. The gene is located on human chromosome llpl5.

Immunogen

The antiserum was produced against synthesized peptide derived from human Tyrosine Hydroxylase around the phosphorylation site of Ser19.

Immunogen Range: 10-59

Biochem./physiol. Wirkung

Th (tyrosine hydroxylase) plays an important role in catecholamine synthesis as it helps in the hydroxylation of L-tyrosine to l-DOPA (l-3,4-dihydroxyphenylalanine). Th gene mutation results in tyrosine hydroxylase deficiency.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency
Korner G, et al.
Brain (2015)
The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13
Boehm T, et al.
Proceedings of the National Academy of Sciences of the USA, 88(10), 4367-4371 (1991)
Izel Tekin et al.
Parkinsonism & related disorders, 23, 86-90 (2016-01-07)
Many of the symptoms and signs of Parkinson's disease (PD) arise from the death of midbrain dopamine neurons that utilize tyrosine hydroxylase (TH) as the rate-limiting enzyme in catecholamine biosynthesis. We investigated whether the presence of a common TH polymorphism

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