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Merck

SAB4502973

Sigma-Aldrich

Anti-TIMP3 antibody produced in rabbit

affinity isolated antibody

Synonym(e):

Metalloproteinase inhibitor 3, Protein MIG-5, TIMP-3, Tissue inhibitor of metalloproteinases 3

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 24 kDa

Speziesreaktivität

mouse, rat, human

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:10000
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... TIMP3(7078)

Allgemeine Beschreibung

Tissue inhibitor of metalloproteinases 3 (TIMP3) belongs to the matrix metalloproteinases inhibitor family. TIMP3 gene is mapped to human chromosome 22q12.3. TIMP3 possesses a C-terminal N-linked glycosylation site at asparagine residue. This protein comprises 12 conserved cysteine residues stabilized by six disulfide bonds in its secondary structure. TIMP-3 gene expression is higher in murine lung and kidney.

Immunogen

The antiserum was produced against synthesized peptide derived from human TIMP3.

Immunogen Range: 91-140

Biochem./physiol. Wirkung

Tissue inhibitor of metalloproteinases 3 (TIMP3) inhibits membrane-type matrix metalloproteinases (MT-MMPs) and the tumor necrosis factor α–converting enzyme (TACE). It displays a high affinity for the proteoglycans associated with extracellular matrix (ECM) and displays tight binding with sulfated glycosaminoglycans. Mutations in the TIMP-3 gene is implicated in Sorsby′s fundus dystrophy which is characterized by choroidal neovascularization, vision loss, and abnormal Bruch′s membrane thickening. Downregulation of TIMP3 gene due to allelic losses on 22q12 chromosomal location is correlated to meningiomas. TIMP3 participates in cardiac remodeling. Low levels of TIMP3 protein are observed in scenarios of ischemic and dilated cardiomyopathy. This protein elicits proapoptotic activity and is an inhibitor of angiogenesis and tumor growth.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Dimitri Barski et al.
Brain pathology (Zurich, Switzerland), 20(3), 623-631 (2009-11-20)
The gene for the tissue inhibitor of metalloproteinase 3 (TIMP3) on 22q12.3 had been reported to be inactivated by promoter methylation in various types of cancers, with controversial findings in meningiomas. We performed direct sodium bisulfite sequencing in a series
Anne M Macgregor et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 57(3), 207-213 (2008-10-29)
Tissue inhibitor of matrix metalloproteinase-3 (TIMP-3) is an important regulator of matrix metalloproteinase activity in many types of disease, including atherosclerosis, neoplasia, and inflammatory conditions. Among TIMPs, TIMP-3 uniquely binds the extracellular matrix (ECM). We performed IHC staining on 17
Likun Yang et al.
Molecular medicine reports, 23(5) (2021-03-25)
Mycoplasma pneumoniae pneumonia (MPP) is a type of pneumonia induced by M. pneumoniae (MP) infection. The present study investigated the effect of long non‑coding RNA growth arrest‑specific 5 (GAS5) in MPP and the underlying molecular mechanism of this. The expression of GAS5
Jingjing Zhang et al.
Molecular and cellular biochemistry, 398(1-2), 123-134 (2014-09-10)
Retinal pigment epithelium (RPE) exerts critical roles in the maintenance of the normal functions of the retina, whereas RPE dysfunction can induce retina neovascularization. p75 neurotrophin receptor (p75(NTR)) has been shown to play essential roles in angiogenesis. However, the function

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