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Key Documents

SAB4502850

Sigma-Aldrich

Anti-SREBP-1 antibody produced in rabbit

affinity isolated antibody

Synonym(e):

SRBP1, SREBF1, SREBP1, sterol regulatory element-binding protein 1, sterol regulatory element-binding transcription factor 1

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About This Item

MDL-Nummer:
MFCD02264110
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

100

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 121 kDa

Speziesreaktivität

human, rat

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

P36956

UniProt-Hinterlegungsnummer

P36956

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... SREBF1(6720)

Allgemeine Beschreibung

Anti-SREBP-1 Antibody detects endogenous levels of total SREBP-1 protein.
Sterol regulatory element binding protein-1 (SREBP1) is located on human chromosome 17p11.2. It belongs to the bHLH-Zip transcription factor family. SREBP-1 is a membrane-bound transcription factor liberated by sterol-regulated proteolysis.It is a 125 kD precursor that is bound to the nuclear envelope and endoplasmic reticulum.

Immunogen

The antiserum was produced against synthesized peptide derived from human SREBP-1.

Immunogen Range: 405-454

Biochem./physiol. Wirkung

Sterol regulatory element binding protein-1 (SREBP1) participates in the transcriptional regulation of cellular lipid homeostasis. It controls the hepatic gene expression of lipogenic enzymes and triglyceride deposition in the liver.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Absence of sterol regulatory element-binding protein-1 (srebp-1) ameliorates fatty livers but not obesity or insulin resistance inlep ob/lep ob mice.
Yahagi N, et al.
The Journal of Biological Chemistry, 277(22), 19353-19357 (2002)
The membrane anchor of the transcriptional activator SREBP is characterized by intrinsic conformational flexibility.
Linser R, et al.
Proceedings of the National Academy of Sciences of the USA, 112(40), 12390-12395 (2015)
Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11. 2 and 22q13.
Hua X, et al.
Genomics, 25(3), 667-673 (1995)
Chien-Chih Chen et al.
Scientific reports, 7(1), 10901-10901 (2017-09-09)
Atypical antipsychotics (AAPs) are considered to possess superior efficacy for treating both the positive and negative symptoms of schizophrenia; however, AAP use often causes excessive weight gain and metabolic abnormalities. Recently, several reports have demonstrated that AAPs activate sterol regulatory
Mathieu Schmitt et al.
Synapse (New York, N.Y.), 71(9) (2017-04-14)
The therapeutic use of statins has been associated to a reduced risk of Parkinson's disease (PD) and may hold neuroprotective potential by counteracting the degeneration of dopaminergic neurons. Transcriptional activation of the sterol regulatory element-binding protein (SREBP) is one of
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