SAB4500378

Anti-Collagen IV α3 (Cleaved-Pro¹⁴²⁶) antibody produced in rabbit

affinity isolated antibody

• Synonym(e): CO4A3, COL4A3, Collagen α-3(IV) chain, Goodpasture antigen, Tumstatin
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 27 kDa
• Speziesreaktivität: human
• Konzentration: ~1 mg/mL
• Methode(n): ELISA: 1:40000; western blot: 1:500-1:1000
• NCBI-Hinterlegungsnummer: Q01955
• UniProt-Hinterlegungsnummer: Q01955
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: proteolytically cleaved (Pro1426)
• Angaben zum Gen: human ... COL4A3(1285)

Beschreibung

Allgemeine Beschreibung

Collagen type IV alpha 3 chain (COL4A3) gene with 52 exons, codes for the α3 chain of type IV collagen. COL4A3 protein is the vital structural protein in the basement membrane. COL4A3 gene is located on human chromosome 2q36.3. Anti-Collagen IV α3 (cleaved-pro1426) antibody detects endogenous levels of fragment of activated collagen IV α3 (cleaved-pro1426) protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human Collagen IV alpha3.

Immunogen Range: 1407-1456

Biochem./physiol. Wirkung

Type IV collagen plays a key role in cell adhesion, proliferation, migration, survival, and differentiation. It maintains the assembly and mechanical stability by acting as a scaffold. Collagen type IV alpha 3 chain (COL4A3) mutations are associated with Alport syndrome (AS). Heterozygous mutations in the COL4A4 gene are observed in individuals with benign familial hematuria (BFH). Alterations in the COL4A3 gene also result in diabetic kidney disease from maturity-onset diabetes.

Leistungsmerkmale und Vorteile

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Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable