SAB4301078

Anti-TDP2 antibody produced in rabbit

affinity isolated antibody

• Synonym(e): AD022, EAP2, EAPII, TTRAP, hTDP2
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: 41 kDa
• Speziesreaktivität: human, mouse
• Konzentration: 2.6 mg/mL
• Methode(n): immunohistochemistry: 1:50- 1:200; western blot: 1:200-1:1000 (Cell Lysate)
• Isotyp: IgG
• Hinterlegungsnummer: NP_057698.2
• UniProt-Hinterlegungsnummer: O95551
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... TDP2(51567)

Beschreibung

Allgemeine Beschreibung

Tyrosyl DNA phosphodiesterase-2 (TDP2) is a multi-functional protein and is also called as TTRAP (TNF receptor-associated protein). It is a 5^′- tyrosyl DNA phosphodiesterase that belongs to the PML NB (promyelocytic leukemia nuclear body) protein family. TDP2 is mapped to human chromosome 6p22.

Spezifität

The antibody detects endogenous levels of total TDP2 protein.

Immunogen

Synthetic peptide corresponding to a region derived from internal residues of human tyrosyl-DNA phosphodiesterase 2

Biochem./physiol. Wirkung

Chromosomal translocations stimulated by DNA topoisomerase II at the time of gene transcription is repressed by tyrosyl DNA phosphodiesterase-2 (TDP2). It is essential to preserve the chromosome stability in human cells. TDP2 participates in cell proliferation, apoptosis and the repair of DNA damage. It promotes cell cycle arrest and apoptosis in osteosarcoma cells.

Leistungsmerkmale und Vorteile

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Physikalische Form

Rabbit IgG in pH7.3 PBS, 0.05% NaN₃, 50% Glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable