SAB4301060

Anti-ARFGEF2 antibody produced in rabbit

affinity isolated antibody

• Synonym(e): BIG2, PVNH2, dJ1164I10.1
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: 202 kDa
• Speziesreaktivität: mouse, human
• Konzentration: 3.4 mg/mL
• Methode(n): immunohistochemistry: 1:50- 1:200; western blot: 1:200-1:1000 (Cell Lysate)
• Isotyp: IgG
• Hinterlegungsnummer: NP_006411.2
• UniProt-Hinterlegungsnummer: Q9Y6D5
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... ARFGEF2(10564)

Beschreibung

Allgemeine Beschreibung

ADP ribosylation factor guanine nucleotide exchange factor 2 (ARFGEF2) possesses a Sec7 domain which is crucial for its activity. This protein is expressed in the brain and the gene encoding it is localized on human chromosome 20.

Spezifität

The antibody detects endogenous levels of total ARFGEF2 protein.

Immunogen

Synthetic peptide corresponding to a region derived from internal residues of human ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)

Biochem./physiol. Wirkung

ADP ribosylation factor guanine nucleotide exchange factor 2 (ARFGEF2) activates ADP-ribosylation factors (ARFs) by exchanging guanosine diphosphate (GDP) with guanosine triphosphate (GTP). It aids in the release of type I tumor necrosis factor receptor (TNFR1) from human umbilical vein endothelial cells. Mutation in the ARFGEF2 gene has been linked to microcephaly and periventricular heterotopia.

Leistungsmerkmale und Vorteile

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Physikalische Form

Rabbit IgG in pH7.3 PBS, 0.05% NaN₃, 50% Glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable