SAB4200266

Anti-PP2A, C subunit antibody, Mouse monoclonal

clone 7A6, purified from hybridoma cell culture

• Synonym(e): MonoclonalAnti-PP2Ac, MonoclonalAnti-PP2CA, MonoclonalAnti-PP2Calpha, MonoclonalAnti-PPP2CA, MonoclonalAnti-RP-C, MonoclonalAnti-protein phosphatase 2, catalytic subunit, alpha isozyme
• UNSPSC-Code: 12352203
• NACRES: NA.44

Eigenschaften

• Biologische Quelle: mouse
• Konjugat: unconjugated
• Antikörperform: purified from hybridoma cell culture
• Antikörper-Produkttyp: primary antibodies
• Klon: 7A6, monoclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 36 kDa
• Speziesreaktivität: human, mouse, rat
• Konzentration: ~1.0 mg/mL
• Methode(n): immunoprecipitation (IP): suitable; western blot: 1-2 μg/mL using whole extracts of mouse 3T3, rat Rat2 or human A431 cells.
• Isotyp: IgG1
• UniProt-Hinterlegungsnummer: P67775
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... PPP2CA(5515) ; mouse ... Ppp2ca(19052) ; rat ... Ppp2ca(24672)

Beschreibung

Allgemeine Beschreibung

PP2A is a serine/threonine phosphatase that downregulates the MAP kinase pathway and subsequently modulates mitogenic signaling. This phosphatase also mediates localization of Sgo1 at centromeres, Ras-1 activation, and chromosome segregation. The catalytic subunit of PP2A (PP2Ac) regulates the signaling pathway for glucose-stiμLated insulin secretion .

Spezifität

Monoclonal Anti-PP2Ac is specific for the α and β isoforms of PP2Ac in humans, rats and mice. The antibody has not been tested in other species for cross-reactivity.

Anwendung

MonoclonalAnti-PP2A, C subunit antibody produced in mouse has been used in immunoblotting and immunoprecipitation.

Biochem./physiol. Wirkung

Protein phosphatase 2A (PP2A) is implicated in the negative control of cell growth and division. PP2Ac undergoes two post-translational modifications, phosphorylation and methylation, which are involved in the regulation of the enzyme activity.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable