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Key Documents

SAB2900053

Sigma-Aldrich

Anti-NR4A1 (AB1) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(e):

Ngfi-b, gfrp1, nak-1, nak1, nerve growth factor inducible-B protein

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

100

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Speziesreaktivität

human

Methode(n)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable

UniProt-Hinterlegungsnummer

P22736

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... NR4A1(3164)

Allgemeine Beschreibung

Nuclear receptor subfamily 4 group A member 1 (NR4A1) is a transcription factor expressed in thymocytes. It is part of an orphan nuclear receptor superfamily. The gene encoding this protein is localized on human chromosome 12.

Immunogen

Synthetic 17 amino acid peptide from internal region of human NUR77. Percent identity with other species by BLAST analysis: Human, Orangutan, Gibbon, Monkey, Horse (100%); Gorilla, Dog, Bat, Panda (94%); Marmoset, Bovine (88%); Mouse, Rat (82%).

Biochem./physiol. Wirkung

Nuclear receptor subfamily 4 group A member 1 (NR4A1) has a role in cell proliferation. It acts as an activator of mechanistic target of rapamycin (mTOR) signaling and regulates apoptosis. The protein modulates genes related to low oxidative stress and growth promotion. NR4A1 has been shown to be expressed in ovarian tumors.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Solution in phosphate-buffered saline containing less than 0.1% sodium azide.

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Lagerklassenschlüssel

10 - Combustible liquids

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Differential Copy Number Aberrations in Novel Candidate Genes Associated with Progression from In Situ to Invasive Ductal Carcinoma of the Breast
Shaoxi Liao
Genes Chromosomes Cancer (2012)
High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome.
Delgado E
Gynecologic Oncology, 141(2) (2016)
Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells.
Ashouri JF and Weiss A
Journal of Immunology, 198(2) (2017)
Nuclear receptor subfamily 4, group A, member 1 inhibits extrinsic apoptosis and reduces caspase-8 activity in H2O2-induced human HUC-F2 fibroblasts.
Shimuzu Y
Redox Report (2015)
Lingli He et al.
Cell reports, 33(3), 108284-108284 (2020-10-22)
The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely unexplored. Here, we identify NR4A1 as a target of the Hippo pathway that mediates the
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