SAB2501761

Anti-ZNF703 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

• Synonym(e): FLJ14299, ZNF503L, hypothetical protein LOC80139, zinc finger protein 703
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: goat
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Speziesreaktivität: pig, canine, human
• Methode(n): indirect ELISA: suitable; western blot: suitable
• UniProt-Hinterlegungsnummer: Q9H7S9
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... ZNF703(80139)

Beschreibung

Allgemeine Beschreibung

ZNF703 (zinc finger protein 703) belongs to the NET (Noc/Nlz, Elbow, and Tlp-1) protein family, and the corresponding gene is localized to human chromosome 8p12.

Immunogen

Peptide with sequence C-ELDKKDQEPKPSPE, from the internal region of the protein sequence according toNP_079345.1

Biochem./physiol. Wirkung

ZNF703 (zinc finger protein 703) is a frequently modified gene in the pan-cancer group. In zebrafish and Drosophila, it plays an essential role in embryonic development. Amplification of this gene leads to loss of cell-cell adhesion, and thus, an increase in proliferation and migration. In patients with head and neck squamous cell carcinomas (HNSCC), the overexpression of this protein is linked with poor overall survival. It functions as an oncogene in luminal B breast cancer and gastric cancer, and in colorectal cancer (CRC) it facilitates tumor proliferation and invasion. In CRC patients, it is linked with poor prognosis.

Leistungsmerkmale und Vorteile

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Physikalische Form

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable