SAB2500814

Anti-PPP1R15A/GADD34 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

• Synonym(e): Anti-GADD34, Anti-Growth arrest and DNA-damage-inducible 34, Anti-Protein phosphatase 1
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: goat
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Speziesreaktivität: human
• Methode(n): immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• UniProt-Hinterlegungsnummer: O75807
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... PPP1R15A(23645)

Beschreibung

Allgemeine Beschreibung

Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) or growth arrest and DNA-damage-inducible 34 (GADD34) is the regulatory subunit of eukaryotic translation initiation factor 2 (eIF2α) phosphatase. It is expressed when there is a signal indicating endoplasmic reticulum stress. The PPP1R15A gene is localized on human chromosome 19q13.33.

Immunogen

Peptide with sequence C-AAALDLSGRRG from the C Terminus of the protein sequence according to NP_055145.2.

Biochem./physiol. Wirkung

Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) recruits and regulates the α-subunit of protein phosphatase 1 (PP1). It functions as a stress marker. When there is depletion in amino acid levels in the cell, PPP1R15A is expressed in high concentrations. It regulates the mammalian target of rapamycin (mTOR) pathway and thereby boosts autophagy in macrophages. Studies have shown that PPP1R15A is expressed in the oligodendrocytes of patients suffering from Alzheimer′s disease.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable