SAB1405511

Anti-BCL3 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

• Synonym(e): BCL4, D19S37
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~46.8 kDa
• Speziesreaktivität: human
• Methode(n): indirect immunofluorescence: suitable; western blot: 1 μg/mL
• NCBI-Hinterlegungsnummer: NM_005178
• UniProt-Hinterlegungsnummer: P20749
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... BCL3(602)

Beschreibung

Allgemeine Beschreibung

B cell lymphoma 3 (BCL3), an oncogene, belongs to the inhibitor of the κ B (IκB) family. It is a nuclear protein with a transactivation domain. BCL3 gene is located on the human chromosome 19q13.

Immunogen

BCL3 (NP_005169.1, 1 a.a. ~ 446 a.a) full-length human protein.

Sequence
MDEGPVDLRTRPKAAGLPGAALPLRKRPLRAPSPEPAAPRGAAGLVVPLDPLRGGCDLPAVPGPPHGLARPEALYYPGALLPLYPTRAMGSPFPLVNLPTPLYPMMCPMEHPLSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQPDPSPDRSANTSPESSSRLSSNGLLSASPSSSPSQSPPRDPPGFPMAPPNFFLPSPSPPAFLPFAGVLRGPGRPVPPSPAPGGS

Biochem./physiol. Wirkung

B cell lymphoma 3 (BCL3) serves as a transcription co-activator. It modulates cyclin D1 transcription in human breast epithelial cells and keratinocytes. BCL3 stabilizes cellular Myc (c-Myc) protein and stimulates tumorigenesis in colorectal cancer cells. It can prevent apoptosis in MCF7AZ breast cancer cells. BCL3 plays a key role in the transcription of cellular inhibitors of apoptosis proteins 1 and 2 (cIAP1 and cIAP2) genes. It might be a possible biomarker in triple-negative breast cancer (TNBC) patients with the basal-like (BL1) subtype.

Physikalische Form

Solution in phosphate buffered saline, pH 7.4

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable