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Merck

SAB1400606

Sigma-Aldrich

Anti-ATAD3A antibody produced in mouse

IgG fraction of antiserum, buffered aqueous solution

Synonym(e):

Anti-FLJ10709

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

mouse

Konjugat

unconjugated

Antikörperform

IgG fraction of antiserum

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Speziesreaktivität

human

Methode(n)

indirect immunofluorescence: suitable
western blot: 1 μg/mL

UniProt-Hinterlegungsnummer

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... ATAD3A(55210)

Verwandte Kategorien

Allgemeine Beschreibung

ATAD3A (ATPase family, AAA domain containing 3A) is mapped to human chromosome 1p36.33. The encoded protein is a localized in mitochondrial membrane.

Immunogen

ATAD3A (AAH33109.1, 1 a.a. ~ 586 a.a) full-length human protein.

Sequence
MSWLFGINKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPKDKWSNFDPTGLERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVAGLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASEDGVLTEAMMDTRVQDAVQQHQQKMCWLKAEGPGRGDEPSPS

Biochem./physiol. Wirkung

ATAD3A (ATPase family, AAA domain containing 3A) was originally considered as a tumor-specific antigen. Mutation in ATAD3A is known to cause a delayed development, optic atrophy, axonal neuropathy, hypotonia and hypertrophic cardiomyopathy. ATAD3A is involved in mitochondrial development, organization of nucleoid, translation of protein, cell growth, and cholesterol metabolism. Downregulation of ATAD3A affects the mitochondrial dynamics, prevents proliferation and changes the interaction between mitochondria and the endoplasmic reticulum. Upregulation of the gene is seen in several cancer types. ATAD3A is known to offer resistance against chemotherapy and radiation. It is responsible for the mitochondrial membrane and import vesicle -mediated transport of AIF (apoptosis inducing factor) from the endoplasmic reticulum into mitochondria. Downregulation of ATAD3A promotes autophagy as well as apoptosis in uterine cervical cancer cells, and also reduces the ability to resist the anticancer drugs. ATAD3A serves as a biomarker for the prognosis of glioblastoma multiforme. It is also found to be involved in cancers such as uterine cervical cancer, lung adenocarcinoma and prostate cancer.

Physikalische Form

Solution in phosphate buffered saline, pH 7.4

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Tamar Harel et al.
American journal of human genetics, 99(4), 831-845 (2016-09-20)
ATPase family AAA-domain containing protein 3A (ATAD3A) is a nuclear-encoded mitochondrial membrane protein implicated in mitochondrial dynamics, nucleoid organization, protein translation, cell growth, and cholesterol metabolism. We identified a recurrent de novo ATAD3A c.1582C>T (p.Arg528Trp) variant by whole-exome sequencing (WES)
Radha Desai et al.
Brain : a journal of neurology, 140(6), 1595-1610 (2017-05-27)
Although mitochondrial disorders are clinically heterogeneous, they frequently involve the central nervous system and are among the most common neurogenetic disorders. Identifying the causal genes has benefited enormously from advances in high-throughput sequencing technologies; however, once the defect is known
Weir-Chiang You et al.
Neuro-oncology, 15(10), 1342-1352 (2013-09-24)
ATPase-family, AAA domain containing 3A (ATAD3A) is located on human chromosome 1p36.33, and high endogenous expression may associate with radio- and chemosensitivity. This study was conducted to investigate the significance of ATAD3A in glioblastoma multiforme (GBM). Clinical significance of ATAD3A
Y Teng et al.
Oncogene, 35(3), 333-343 (2015-03-31)
AAA domain containing 3A (ATAD3A) is an integral mitochondrial membrane protein with unknown function, although we now show that high-level expression is associated with poor survival in breast cancer patients. Using a mass spectrometry approach we have demonstrated that ATAD3A

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