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S8197

Sigma-Aldrich

SMER28

>99% (HPLC), solid

Synonym(e):

6-bromo-N-2-propenyl-4-quinazolinamine

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About This Item

Empirische Formel (Hill-System):
C11H10BrN3
CAS-Nummer:
307538-42-7
Molekulargewicht:
264.12
MDL-Nummer:
MFCD02166825
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329824598
NACRES:
NA.77

Qualitätsniveau

100

Assay

>99% (HPLC)

Form

solid

Löslichkeit

DMSO: >20 mg/mL
H2O: insoluble

Lagertemp.

2-8°C

SMILES String

Brc1ccc2ncnc(NCC=C)c2c1

InChI

1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)

InChIKey

BCPOLXUSCUFDGE-UHFFFAOYSA-N

Anwendung

SMER28 may be used in mTOR-mediated signaling studies.

Biochem./physiol. Wirkung

SMER28 is a small molecule modulator of mammalian autophagy; enhances A53T alpha-synuclein clearance in PC-12 cells independent of rapamycin treatment; appears to act independent of the mTOR pathway, but combined treatment with saturating rapamycin concentration enhances the effect of either compound alone on A53T alpha-synuclein clearance; autophagy inducers may prove useful in the treatment of neurodegenerative and infectious diseases and cancer.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Dee Shen et al.
Cell biochemistry and biophysics, 60(3), 173-185 (2010-12-07)
Aggresomes and related inclusion bodies appear to serve as storage depots for misfolded and aggregated proteins within cells, which can potentially be degraded by the autophagy pathway. A homogenous fluorescence-based assay was devised to detect aggregated proteins inside aggresomes and
Ann K Rosenthal et al.
The Journal of biological chemistry, 290(21), 13028-13038 (2015-04-15)
Chondrocyte-derived extracellular organelles known as articular cartilage vesicles (ACVs) participate in non-classical protein secretion, intercellular communication, and pathologic calcification. Factors affecting ACV formation and release remain poorly characterized; although in some cell types, the generation of extracellular vesicles is associated
Yu Wu et al.
The FEBS journal, 287(15), 3184-3199 (2020-01-05)
The endo-lysosome system is involved in endocytosis, protein sorting, and degradation as well as autophagy. Numerous toxins and pathogens exploit this system to enter host cells and exert their deleterious effects. Modulation of host endo-lysosome pathway may restrict multiple toxins

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