S5826

SYUIQ-5

≥98% (HPLC)

• Synonym(e): N′-(10H-Indolo [3,2-b]quinolin-11-yl)-N, N-dimethyl-propane-1,3-diamine
• Empirische Formel (Hill-System): C₂₀H₂₂N₄
• CAS-Nummer: 188630-47-9
• Molekulargewicht: 318.42
• MDL-Nummer: MFCD17215940
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329824555
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: yellow
• Löslichkeit: DMSO: ≥20 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: CN(C)CCCNc1c2ccccc2nc3c4ccccc4[nH]c13
• InChI: 1S/C20H22N4/c1-24(2)13-7-12-21-18-14-8-3-5-10-16(14)22-19-15-9-4-6-11-17(15)23-20(18)19/h3-6,8-11,23H,7,12-13H2,1-2H3,(H,21,22)
• InChIKey: CTDCVGDSVHUYMA-UHFFFAOYSA-N

Beschreibung

Anwendung

SYUIQ-5 may be used in autophagy and DNA damage-inducing cell signaling studies.

Biochem./physiol. Wirkung

SYUIQ-5 is a Cryptolepine derivative, which induces and stabilizes G-quadruplexes. In CNE2 and HeLa cancer cells SYUIQ-5 triggers rapid and potent telomere DNA damage through TRF2 delocalization from telomeres and induces cell death by autophagy. In low concentration the compound caused senescence and telomere shortening. It is a potent cytotoxic agent.

Sicherheitshinweise

• Piktogramme: GHS09
• Signalwort: Warning
• H-Sätze: H400
• P-Sätze: P273 - P391 - P501
• Gefahreneinstufungen: Aquatic Acute 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable