S4441

D,L-Sulforaphane

≥90% (HPLC), liquid, phase II detoxification enzymes inducer

• Synonym(e): 1-Isothiocyanato-4-(methylsulfinyl)-butane
• Empirische Formel (Hill-System): C₆H₁₁NOS₂
• CAS-Nummer: 4478-93-7
• Molekulargewicht: 177.29
• MDL-Nummer: MFCD00198068
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724610
• NACRES: NA.77

Eigenschaften

• product name: DL-Sulforaphane, ≥90% (HPLC), synthetic, liquid
• Biologische Quelle: synthetic
• Qualitätsniveau: 200
• Assay: ≥90% (HPLC)
• Form: liquid
• Löslichkeit: DMSO: soluble 40 mg/mL; H₂O: insoluble
• Kompatibilität: for use with ABI 7500
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: CS(=O)CCCCN=C=S
• InChI: 1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3
• InChIKey: SUVMJBTUFCVSAD-UHFFFAOYSA-N

Beschreibung

Anwendung

LNCaP prostate cancer cells were treated with DL-Sulforaphane to study the effect on androgen receptor. Effects on malathion toxicity was studied in rats by treating them with DL-Sulforaphane.

Biochem./physiol. Wirkung

Selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.

Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables. It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Persönliche Schutzausrüstung: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)