S4069

SL327

≥98% (HPLC), Mixture of E & Z isomers, solid

• Synonym(e): α-[Amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile, SL 327, SL-327
• Empirische Formel (Hill-System): C₁₆H₁₂F₃N₃S
• CAS-Nummer: 305350-87-2
• Molekulargewicht: 335.35
• MDL-Nummer: MFCD06411432
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329824537
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Lagerbedingungen: desiccated; protect from light
• Farbe: white to off-white
• mp (Schmelzpunkt): 127-128.2 °C
• Löslichkeit: DMSO: >10 mg/mL; H₂O: insoluble
• Lagertemp.: 2-8°C
• SMILES String: N\C(Sc1ccc(N)cc1)=C(\C#N)c2ccccc2C(F)(F)F
• InChI: 1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
• InChIKey: JLOXTZFYJNCPIS-FYWRMAATSA-N

Beschreibung

Anwendung

SL327 has been used as an inhibitor of dual specificity mitogen-activated protein kinase (MEK) in Zebrafish embryos and lymphatic endothelial cell (LEC).

SL327 was used to study the role of MAPK signaling in interictal spiking and behavior of epileptic rats. It was used to study the effect of estradiol on ERK signaling in mouse dorsal hippocampus.

Biochem./physiol. Wirkung

SL327 is a selective MEK1/2inhibitor (IC₅₀ values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)