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S0814

Sigma-Aldrich

Anti-phospho-Serotonin N-Acetyltransferase (N-Terminal) (pThr29) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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About This Item

MDL-Nummer:
MFCD02265746
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

200

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Speziesreaktivität

rat

Methode(n)

western blot: 0.5 μg/mL

UniProt-Hinterlegungsnummer

Q64666

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

phosphorylation (pThr29)

Angaben zum Gen

rat ... Aanat(25120)

Immunogen

synthetic phosphopeptide derived from the N-terminal region of rat AA-NAT that contains threonine 29.

Anwendung

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)

Physikalische Form

Solution in phosphate buffered saline, containing 1 mg/ml BSA and 0.05% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

X Li et al.
Current opinion in neurobiology, 8(5), 648-651 (1998-11-13)
Recent findings have clarified the mechanisms regulating the night- and pineal-specific transcription of serotonin N-acetyltransferase, the rate-limiting enzyme in melatonin formation. Norepinephrine, acting via beta-adrenoceptors and cAMP at night, stimulates the cAMP response element binding protein, which turns on the
Marco A Pires-Lapa et al.
International journal of molecular sciences, 19(8) (2018-07-28)
Melatonin (5-methoxy-N-acetylserotonin), the pineal hormone, is also synthesized by immune-competent cells. The pineal hormone signals darkness, while melatonin synthesized on demand by activated macrophages at any hour of the day acts locally, favoring regulatory/tolerant phenotypes. Activation of β-adrenoceptors in pinealocytes
Sandra Marcia Muxel et al.
PloS one, 7(12), e52010-e52010 (2013-01-04)
We demonstrate that during inflammatory responses the nuclear factor kappa B (NF-κB) induces the synthesis of melatonin by macrophages and that macrophage-synthesized melatonin modulates the function of these professional phagocytes in an autocrine manner. Expression of a DsRed2 fluorescent reporter

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