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S0193

Sigma-Aldrich

SKF-86002

≥98% (HPLC), solid

Synonym(e):

6-(4-Fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole

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About This Item

Empirische Formel (Hill-System):
C16H12N3FS
CAS-Nummer:
72873-74-6
Molekulargewicht:
297.35
MDL-Nummer:
MFCD00869367
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24724598
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

solid

Lagerbedingungen

protect from light

Farbe

off-white

mp (Schmelzpunkt)

189-190 °C (lit.)

Löslichkeit

DMSO: soluble >10 mg/mL

Lagertemp.

2-8°C

SMILES String

Fc1ccc(cc1)-c2nc3SCCn3c2-c4ccncc4

InChI

1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2

InChIKey

YOELZIQOLWZLQC-UHFFFAOYSA-N

Angaben zum Gen

human ... IL1B(3553) , TNF(7124)
rat ... Alox5(25290)

Biochem./physiol. Wirkung

p38 MAP kinase inhibitor.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Donna E Muscarella et al.
Toxicological sciences : an official journal of the Society of Toxicology, 68(1), 82-92 (2002-06-21)
Various forms of inorganic arsenic are significant environmental contaminants that have multiple effects on cells, including the induction of apoptotic cell death. Induction of apoptosis in lymphoid cells can mediate immunotoxicity following exposure to chemicals. However, the mechanisms regulating the
Ganesan Ramesh et al.
American journal of physiology. Renal physiology, 289(1), F166-F174 (2005-02-11)
Cisplatin is an important chemotherapeutic agent but can cause acute renal injury. Part of this acute renal injury is mediated through tumor necrosis factor-alpha (TNF-alpha). The pathway through which cisplatin mediates the production of TNF-alpha and injury is not known.
M Kusuhara et al.
Circulation research, 83(8), 824-831 (1998-10-20)
Activation of the Na+/H+ exchanger isoform-1 (NHE-1) by angiotensin II is an early signal transduction event that may regulate vascular smooth muscle cell (VSMC) growth and migration. Many signal transduction events stimulated by angiotensin II are mediated by the mitogen-activated
Javier Hernández Losa et al.
Oncogene, 22(26), 3998-4006 (2003-06-25)
p38 MAPK has been implicated in the response to cancer therapy. To determine whether the activation of p38 MAPK could be specific to cancer therapy, we investigated the activation of p38 MAPK in response to several chemotherapeutic agents, such as
David J Diller et al.
Current topics in medicinal chemistry, 5(10), 953-965 (2005-09-24)
In the late 1970s and the early 1980s the initial p38 chemotype, the triaryl imidazoles, was discovered as an off-target effect during the development of cyclooxygenase and 5-lipoxygenase inhibitors long before the identity of the p38 kinase was known. During
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