R2530

Ropinirol -hydrochlorid

powder, ≥98% (HPLC)

• Synonym(e): 4-[2-(Dipropylamino)-ethyl]-1,3-dihydro-2H-indol-2-on -hydrochlorid, SKF 101468 -hydrochlorid
• Empirische Formel (Hill-System): C₁₆H₂₄N₂O · HCl
• CAS-Nummer: 91374-20-8
• Molekulargewicht: 296.84
• MDL-Nummer: MFCD01754173
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329824018
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: light yellow
• Löslichkeit: H₂O: >10 mg/mL
• Ersteller: GlaxoSmithKline
• SMILES String: Cl.CCCN(CCC)CCc1cccc2NC(=O)Cc12
• InChI: 1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H
• InChIKey: XDXHAEQXIBQUEZ-UHFFFAOYSA-N
• Angaben zum Gen: human ... DRD2(1813) , DRD3(1814) , DRD4(1815)

Beschreibung

Biochem./physiol. Wirkung

An agonist at the D₂ and D₃ dopamine receptor subtypes, binding with higher affinity to D₃ than to D₂ or D₄. It has negligible effect on D₁-receptors. It has medium in vitro affinity to opioid receptors. Ropinirole is said to have virtually no affinity to 5-HT₁, 5-HT₂, benzodiazepine, GABA, muscarinic, α1-, α2-, and β-adrenoreceptors. Used as antiparkinsonian drug.

Ropinirole hydrochloride is effectively used to treat early and late Parkinson′s disease.

Selective D₂ dopamine receptor agonist, antiparkinsonian

Leistungsmerkmale und Vorteile

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H302,H400
• P-Sätze: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Acute 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves