PZ0317

Capromorelin tartrate

≥98% (HPLC)

• Synonym(e): 2-Amino-N-[(1R)-2-[(3aR)-2,3,3a,4,6,7-hexahydro-2-methyl-3-oxo-3a-(phenylmethyl)-5H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxo-1-propanamide (2R,3R)-2,3-dihydroxybutanedioate, CP 424391-18, CP-424391 tartrate
• Empirische Formel (Hill-System): C₂₈H₃₅N₅O₄ · C₄H₆O₆
• CAS-Nummer: 193273-69-7
• Molekulargewicht: 655.70
• MDL-Nummer: MFCD25977748
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 329823835
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: H₂O: 20 mg/mL, clear
• Lagertemp.: room temp
• SMILES String: O=C1N(C)N=C2CCN(C([C@H](NC(C(C)(C)N)=O)COCC3=CC=CC=C3)=O)C[C@]21CC4=CC=CC=C4.OC([C@H](O)[C@@H](O)C(O)=O)=O
• InChI: 1S/C28H35N5O4.C4H6O6/c1-27(2,29)25(35)30-22(18-37-17-21-12-8-5-9-13-21)24(34)33-15-14-23-28(19-33,26(36)32(3)31-23)16-20-10-6-4-7-11-20;5-1(3(7)8)2(6)4(9)10/h4-13,22H,14-19,29H2,1-3H3,(H,30,35);1-2,5-6H,(H,7,8)(H,9,10)/t22-,28-;1-,2-/m11/s1
• InChIKey: MJGRJCMGMFLOET-MYPSAZMDSA-N

Beschreibung

Allgemeine Beschreibung

Capromorelin tartrate has been used in human clinical trials as a treatment for frailty in elderly adults.

Capromorelin tartrate is an agonist of GHSR1a (ghrelin) receptors. It possesses structural homology with pyrazolinone-piperidine dipeptides.

Biochem./physiol. Wirkung

Capromorelin tartrate is a potent ghrelin receptor agonist/growth hormone secretagogue (Ki = 7 nM). In rat pituitary cells, Capromorlelin incudes growth hormone (GH) secretion with an EC₅₀ of 3 nM. Capromorelin also increases gastric motility and has been studied recently in patients with spinal cord injuries.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3