PZ0254

PF-06273340

≥98% (HPLC)

• Synonym(e): N-(5-{[2-Amino-7-(2-hydroxy-1 ,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5- yl]carbonyl}pyridin-3-yl)-2-(5-chloropyridin-2-yl)acetamide, N-[5-[[2-Amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl]-3-pyridinyl]-5-chloro-2-pyridineacetamide, PF 06273340, PF06273340
• Empirische Formel (Hill-System): C₂₃H₂₂ClN₇O₃
• CAS-Nummer: 1402438-74-7
• Molekulargewicht: 479.92
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 329823793
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: , white to yellow to brown
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: room temp
• SMILES String: CC(CO)(C)N1C2=NC(N)=NC=C2C(C(C3=CN=CC(NC(CC4=CC=C(Cl)C=N4)=O)=C3)=O)=C1
• InChI: 1S/C23H22ClN7O3/c1-23(2,12-32)31-11-18(17-10-28-22(25)30-21(17)31)20(34)13-5-16(9-26-7-13)29-19(33)6-15-4-3-14(24)8-27-15/h3-5,7-11,32H,6,12H2,1-2H3,(H,29,33)(H2,25,28,30)
• InChIKey: BPIWZDNVMQQBQX-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

PF-06273340 is a brain penetrant, orally available and potent tropomyosin-related kinase (Trk) inhibitor. PF-06273340 is under development as a remedy acute and chronic pain.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable