PZ0137

CP-471474

≥98% (HPLC)

• Synonym(e): 2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydrox y-2-methylpropanamide, PF-1626077
• Empirische Formel (Hill-System): C₁₆H₁₇FN₂O₅S
• CAS-Nummer: 210755-45-6
• Molekulargewicht: 368.38
• MDL-Nummer: MFCD16618408
• UNSPSC-Code: 41121801
• PubChem Substanz-ID: 329823722
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to off-white
• Löslichkeit: DMSO: ≥20 mg/mL
• Lagertemp.: room temp
• SMILES String: CC(C)(NS(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1)C(=O)NO
• InChI: 1S/C16H17FN2O5S/c1-16(2,15(20)18-21)19-25(22,23)14-9-7-13(8-10-14)24-12-5-3-11(17)4-6-12/h3-10,19,21H,1-2H3,(H,18,20)
• InChIKey: QCOQJYRPDUMCNP-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

CP-471474 is a broad spectrum inhibitor of matrix metalloproteinases. CP-471474 has a low nM IC₅₀ efficacy for MMP-2, MMP-3, MMP-9, and MMP-13. CP-471474 has low potency against MMP-1 (IC₅₀ > 1 uM). CP-471474 prevents left ventricular remodeling after experimental myocardial infarction in mice. CP-471474 also inhibits cigarette smoke-induced lung inflammation and the progression of emphysema in guinea pig models.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable