PZ0115

CP-31398 dihydrochloride hydrate

≥98% (HPLC)

• Synonym(e): N′-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine dihydrochloride hydrate
• Empirische Formel (Hill-System): C₂₂H₂₆N₄O·2HCl · xH₂O
• Molekulargewicht: 435.39 (anhydrous basis)
• MDL-Nummer: MFCD17215956
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329823707
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Lagerbedingungen: desiccated
• Farbe: yellow
• Löslichkeit: H₂O: ≥20 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: O.Cl.Cl.COc1ccc(cc1)\C=C\c2nc(NCCCN(C)C)c3ccccc3n2
• InChI: 1S/C22H26N4O.2ClH.H2O/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17;;;/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25);2*1H;1H2/b14-11+;;;
• InChIKey: JXIVIAMOMIONKY-UWCBQFGESA-N
• Angaben zum Gen: human ... TP53(7157) ; mouse ... TP53(22059) ; rat ... TP53(24842)

Beschreibung

Anwendung

CP-31398 dihydrochloride hydrate has been used as a p53 stabilizer:

• to evaluate its effects on the upregulation of miRNA in human neuroblastoma cells
• to study its effects on arsenic trioxide (ATO) stabilization of p53 folding
• to study its effects on regulation of miR-34 in PC12 cells

Biochem./physiol. Wirkung

CP-31398 is a styryl quinazoline that functions in preserving the activity of p53 as a tumor suppressor and transcription factor. The DNA-binding activity and apoptosis functionality of the p53 are restored by CP-31398. CP-31398 exhibits therapeutic effects against liver, skin, pancreatic, and colon cancers.

CP-31398 dihyrochloride hydrate is a p53 stabilizer; apoptosis inducer.

Leistungsmerkmale und Vorteile

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302 - H315 - H319 - H413
• P-Sätze: P264 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable