P5052

5α-Pregnan-3α-ol-11,20-dione

powder, ≥98% (TLC)

• Synonym(e): 3-Hydroxy-5α-pregnane-11,20-dione, Alfaxalone
• CAS-Nummer: 23930-19-0
• MDL-Nummer: MFCD00083468
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278637
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥98% (TLC)
• Form: powder
• Arzneimittelkontrolle: USDEA Schedule IV
• Farbe: white
• Löslichkeit: chloroform: ≥5 mg/mL, clear, colorless
• SMILES String: [H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(C)=O)[C@@]4(C)CC(=O)[C@]3([H])[C@@]1(C)CC[C@@H](O)C2
• InChI: 1S/C21H32O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h13-17,19,23H,4-11H2,1-3H3/t13-,14+,15-,16+,17-,19+,20-,21+/m0/s1
• InChIKey: DUHUCHOQIDJXAT-OLVMNOGESA-N
• Angaben zum Gen: human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRG2(2566)

Beschreibung

Biochem./physiol. Wirkung

Synthetic steroid compound alphaxalone (AFX) - 5α-Pregnan-3α-ol-11,20-dione- is a neurosteroid that directly activates and potentiates GABA_A receptor-activated membrane current (IGABA). It acts as a positive allosteric modulator of the GABA_A receptor; anesthetic. The alpha subunit subtype of GABA_A determines the efficacy, but not the potency, of AFX neuroactive steroid to potentiate IGABA.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P301 + P310
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves