P1499

Pterostilben

≥97% (HPLC), solid

• Synonym(e): Pterocarpus marsupium, 3,5-Dimethoxy-4′-hydroxystilbene, 4-[(1E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenol
• Empirische Formel (Hill-System): C₁₆H₁₆O₃
• CAS-Nummer: 537-42-8
• Molekulargewicht: 256.30
• MDL-Nummer: MFCD00238710
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724573
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: solid
• Lagerbedingungen: protect from light
• Löslichkeit: DMSO: >20 mg/mL; H₂O: insoluble
• Lagertemp.: 2-8°C
• SMILES String: COc1cc(OC)cc(\C=C\c2ccc(O)cc2)c1
• InChI: 1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+
• InChIKey: VLEUZFDZJKSGMX-ONEGZZNKSA-N

Beschreibung

Allgemeine Beschreibung

Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene), an antioxidant is an analogue of resveratrol. It is present in blueberries, tree wood and some types of grapes.

Anwendung

Pterostilbene has been used:

• to investigate its anti-oxidative stress activities and the involvement of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-antioxidant response element (ARE) signaling pathway
• to determine its effects on transcriptional activation of estrogen receptor-α (ERα) in hormone resistant breast cancer cells)
• to study its effects on the cytotoxicity of 2-chloroethyl ethyl sulphide (CEES) in human epidermoid carcinoma cells (A-431) through MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide)viability assay

Biochem./physiol. Wirkung

Antioxidant, antiproliferative, apoptosis inducer, antihyperglycemic, antidiabetic.

Pterostilbene exhibits antineoplastic properties in some of the malignancies, hence it is considered as an active anticancer agent. It has the ability to stimulate apoptosis and block the viability of cell in estrogen-receptor positive and negative breast cancer cell lines.

Vorsicht

Air-sensitive

Sicherheitshinweise

• Piktogramme: GHS05,GHS09
• Signalwort: Danger
• H-Sätze: H318,H411
• P-Sätze: P273 - P280 - P305 + P351 + P338 + P310
• Gefahreneinstufungen: Aquatic Chronic 2 - Eye Dam. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves