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P0928

Sigma-Aldrich

O7-Pentylresorufin

Synonym(e):

7-Pentyloxy-3H-phenoxazin-3-on, Pentoxyresorufin

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About This Item

Empirische Formel (Hill-System):
C17H17NO3
CAS-Nummer:
87687-03-4
Molekulargewicht:
283.32
Beilstein:
8394939
MDL-Nummer:
MFCD00037664
UNSPSC-Code:
12161501
PubChem Substanz-ID:
24898138
NACRES:
NA.47

Assay

≥98% (TLC)

Qualitätsniveau

200

Form

powder

Löslichkeit

acetonitrile: 0.95- 1.05 mg/mL, clear, orange

Lagertemp.

2-8°C

SMILES String

CCCCCOc1ccc2N=C3C=CC(=O)C=C3Oc2c1

InChI

1S/C17H17NO3/c1-2-3-4-9-20-13-6-8-15-17(11-13)21-16-10-12(19)5-7-14(16)18-15/h5-8,10-11H,2-4,9H2,1H3

InChIKey

ZPSOKQFFOYYPKC-UHFFFAOYSA-N

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Allgemeine Beschreibung

Resorufin pentyl ether is an analog of resazurin. Resorufin is a redox probe which is colorless and non-fluorescent in its reduced state. On oxidation, it fluoresces red. Resorufin is used widely as an indicator in microbiological media. It can be used to differentiate between actively metabolizing cells and inactive or dead cells.

Anwendung

Resorufin pentyl ether has been used as a substrate to study the effects of Kaempferia parviflora extract on mouse hepatic cytochrome P450 enzymes.

Biochem./physiol. Wirkung

Fluorimetric substrate for cytochrome P450 linked enzymes, CYP2B and CYP2B4.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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A Pietersma et al.
Free radical research, 28(2), 137-150 (1998-06-30)
The present study was undertaken to investigate the hypothesis that multiple oxygen radical generating systems contribute to the tumor necrosis factor (TNF) alpha-stimulated transcriptional activation of the vascular cell adhesion molecule (VCAM)-1 in endothelial cells. Experimental evidence has implicated the
Microbial Biofilms null
V Burkina et al.
Ecotoxicology and environmental safety, 79, 148-152 (2012-01-17)
Little is known about the effects of the cardiovascular drug verapamil (VRP) on metabolic processes in fish. Most calcium channel blockers including VRP are metabolized by cytochrome P450 (CYP450) enzymes. In this study we investigated the in vivo effect of
Modulatory effects of Kaempferia parviflora extract on mouse hepatic cytochrome P450 enzymes
Catheleeya Mekjaruskul
Journal of Ethnopharmacology, 141(3) (2012)
E S Tzanakakis et al.
Cell motility and the cytoskeleton, 48(3), 175-189 (2001-02-27)
Cultured rat hepatocytes self-assemble into three-dimensional structures or spheroids that exhibit ultrastructural characteristics of native hepatic tissue and enhanced liver-specific functions. The spheroid formation process involves cell translocation and changes in cell shape, indicative of the reorganization of the cytoskeletal
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Artikel

Phase I Drug Metabolism

Phase I biotransformation reactions introduce or expose functional groups on the drug with the goal of increasing the polarity of the compound. Although Phase I drug metabolism occurs in most tissues, the primary and first pass site of metabolism occurs during hepatic circulation.

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