P0106

Pefloxacin -mesylat Dihydrat

• Synonym(e): 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-, monomethanesulfonate, dihydrate, Pefloxacine monomethanesulfonate dihydrate, Pefloxacinium methanesulfonate dihydrate
• Lineare Formel: C₁₇H₂₀FN₃O₃ • CH₄O₃S • 2H₂O
• CAS-Nummer: 149676-40-4
• Molekulargewicht: 465.49
• EG-Nummer: 274-613-9
• MDL-Nummer: MFCD01685696
• UNSPSC-Code: 51102829
• PubChem Substanz-ID: 329820015
• NACRES: NA.76

Eigenschaften

• Form: powder
• Qualitätsniveau: 100
• Löslichkeit: H₂O: 50 mg/mL
• Wirkungsspektrum von Antibiotika: Gram-negative bacteria; Gram-positive bacteria
• Wirkungsweise: DNA synthesis | interferes; enzyme | inhibits
• Lagertemp.: 2-8°C
• SMILES String: O.O.CS(O)(=O)=O.CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCN(C)CC3
• InChI: 1S/C17H20FN3O3.CH4O3S.2H2O/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21;1-5(2,3)4;;/h8-10H,3-7H2,1-2H3,(H,23,24);1H3,(H,2,3,4);2*1H2
• InChIKey: LEULAXMUNMRLPW-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Chemical structure: fluoroquinolone

Anwendung

Pefloxacin is a synthetic broad-spectrum fluoroquinolone antibiotic that is effective against most gram-negative and gram-positive bacteria. It is used to treat gonococcal urethritis and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract. Pefloxacin mesylate dihydrate has been used to induce achilles tendon toxicity in rodents. It′s cytotoxicity and uptake have been studied in primary cultures of rat hepatocytes.

Biochem./physiol. Wirkung

Pefloxacin inhibits the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited . Pefloxacin is an analog of norfloxacin.

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H319
• P-Sätze: P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves