P0081

Monoclonal Anti-PMP22 antibody produced in mouse

~1.0 mg/mL, clone CF1, purified immunoglobulin, buffered aqueous solution

• Synonym(e): Anti-CMT1A, Anti-Charcot-Marie-Tooth neuropathy 1A, Anti-GAS3, Anti-Growth arrest-specific 3, Anti-HNPP, Anti-Peripheral myelin protein 22
• UNSPSC-Code: 12352203

Eigenschaften

• Biologische Quelle: mouse
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: CF1, monoclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~22 kDa
• Speziesreaktivität: human, monkey
• Verpackung: antibody small pack of 25 μL
• Konzentration: ~1.0 mg/mL
• Methode(n): immunocytochemistry: suitable; immunohistochemistry: 2.5-5 μg/mL using human spinal cord tissue sections.; indirect ELISA: suitable; western blot: suitable
• Isotyp: IgG1
• UniProt-Hinterlegungsnummer: Q01453
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... PMP22(5376)

Beschreibung

Allgemeine Beschreibung

Peripheral myelin protein 22 (PMP22), also known as growth arrest-specific protein 3 (GAS-3), is a tetraspan glycoprotein. It is highly expressed in myelin-forming Schwann cells of peripheral nerves. The gene encoding it is localized on human chromosome 17p12–13.

Immunogen

peptide corresponding to the second extracellular domain of human PMP22 (amino acids 120-133).

Biochem./physiol. Wirkung

Peripheral myelin protein 22 (PMP22) plays a vital role in myelination during peripheral nerve development. It also has a role in cell-cell interactions, cell proliferation, maintenance of axons and the determination of myelin thickness and stability. Aberrations or mutations in the PMP22 gene lead to heritable demyelinating peripheral neuropathies, such as Charcot-Marie-tooth disease type IA (CMT1A) and Dejerine-Sottas syndrome. Overexpression of PMP22 might contribute to the development of chronic myeloid leukemia (CML).

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)