P0069

PRIMA-1

≥98% (HPLC), solid

• Synonym(e): 2,2-Bishydroxymethyl-1-aza-bicyclo[2.2.2]octan-3-one
• Empirische Formel (Hill-System): C₉H₁₅NO₃
• CAS-Nummer: 5608-24-2
• Molekulargewicht: 185.22
• MDL-Nummer: MFCD04974196
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329820004
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: solid
• Farbe: white to off-white
• Löslichkeit: H₂O: >10 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: OCC1(CO)N2CC[C@@H](CC2)C1=O
• InChI: 1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2
• InChIKey: RFBVBRVVOPAAFS-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

P53-dependent reactivation and induction of massive apoptosis (PRIMA-1) is a low molecular weight compound and has a role in cancer therapy. PRIMA-1 stimulates cytotoxic effects in human cancer cells. It induces eryptosis.

Biochem./physiol. Wirkung

PRIMA-1 is a selective re-activator of mutant p53 activity in tumor cells, and an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53. Mutations in the tumor suppressor p53 take place in >50% tumor cells. PRIMA-1 selectively restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at μM concentrations. PRIMA-1 works as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Danger
• H-Sätze: H302,H334
• P-Sätze: P301 + P312 + P330
• Gefahreneinstufungen: Acute Tox. 4 Oral - Resp. Sens. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves