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Key Documents

O0766

Sigma-Aldrich

ONO-RS-082

≥97% (HPLC)

Synonym(e):

2-(p-Amylcinnamoyl)amino-4-chlorobenzoic acid, 4-Chloro-2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-benzoic acid

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About This Item

Empirische Formel (Hill-System):
C21H22ClNO3
CAS-Nummer:
99754-06-0
Molekulargewicht:
371.86
UNSPSC-Code:
41106300
NACRES:
NA.77

Assay

≥97% (HPLC)

Form

powder

Haltbarkeit

Do not freeze

Lagerbedingungen

protect from light

Farbe

white

Löslichkeit

DMSO: ≥20 mg/mL

Lagertemp.

room temp

InChI

1S/C21H22ClNO3/c1-2-3-4-5-15-6-8-16(9-7-15)10-13-20(24)23-19-14-17(22)11-12-18(19)21(25)26/h6-14H,2-5H2,1H3,(H,23,24)(H,25,26)/b13-10+

InChIKey

MDVFITMPFHDRBZ-JLHYYAGUSA-N

Biochem./physiol. Wirkung

ONO-RS-082 is a reversible phospholipase A2 inhibitor.

Leistungsmerkmale und Vorteile

This compound is featured on the Phospholipase A2 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Piktogramme

Environment
GHS09

Signalwort

Warning

H-Sätze

H410

Gefahreneinstufungen

Aquatic Acute 1 - Aquatic Chronic 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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L Domínguez et al.
International journal of andrology, 19(4), 248-252 (1996-08-01)
Phospholipase A2 (PLA2, EC 3.1.1.4) is involved in the cascade of signalling events leading to the acrosome reaction in human spermatozoa. In order to study the role of PLA2 in the acrosome reaction triggered by GTP gamma S, a non-hydrolizable
Rania Abu-Hamdah et al.
Cell biology international, 28(1), 7-17 (2004-02-05)
Aquaporins (AQP) are involved in rapid and active gating of water across biological membranes. The molecular regulation of AQP is unknown. Here we report the isolation, identification and reconstitution of the regulatory complex of AQP-1. AQP-1 and Galphai3 have been
Y Li et al.
American journal of physiology. Heart and circulatory physiology, 280(6), H2658-H2664 (2001-05-18)
Physiological concentrations of [Arg(8)]vasopressin (AVP; 10-500 pM) stimulate oscillations of cytosolic free Ca2+ concentration (Ca2+ spikes) in A7r5 vascular smooth muscle cells. We previously reported that this effect of AVP was blocked by a putative phospholipase A2 (PLA2) inhibitor, ONO-RS-082
H Yoshida et al.
The American journal of physiology, 273(3 Pt 1), G735-G747 (1997-10-08)
In an attempt to examine the structure-activity relationship of the cholecystokinin (CCK) peptide, we examined the structural motif of CCK truncated peptides responsible for rat pancreatic acinar amylase secretion and signal transduction. CCK-6 (Met28-Gly29-Trp30-Met31-Asp32-Phe33 -NH2), CCK-5 [CCK-(29-33)], and CCK-4 [CCK-(30-33)]
K L Byron
Circulation research, 78(5), 813-820 (1996-05-01)
[Arg8]-vasopressin (AVP) is both a potent vasoconstrictor and a mitogen for vascular smooth muscle cells. AVP binds to a single class of receptors (V1a) in the A7r5 rat aortic smooth muscle cell line (Kd approximately 2 nmol/L). Stimulation of these
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Artikel

Phospholipase A2

Phospholipase A2 (PLA2) designates a class of enzymes that hydrolyze the sn-2 ester of glycerophospholipids to produce a fatty acid and a lysophospholipid. It has become clear that some of these enzymes liberate arachidonic acid in mammalian cells for the biosynthesis of eicosanoids, and thus there has been considerable interest in developing PLA2 inhibitors. Based on amino acid sequences, there are now more than 12 distinct groups of mammalian PLA2s, as well as many non-mammalian forms, all of which have been classified into 14 distinct groups with many subgroups.

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