N8162

NIDA-41020

≥97% (HPLC), solid

• Synonym(e): 1-(2,4-Dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide
• Empirische Formel (Hill-System): C₂₃H₂₄Cl₂N₄O₂
• CAS-Nummer: 502486-89-7
• Molekulargewicht: 459.37
• MDL-Nummer: MFCD08277026
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329818682
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: solid
• Farbe: off-white
• Löslichkeit: DMSO: ~16 mg/mL; H₂O: insoluble
• Lagertemp.: 2-8°C
• SMILES String: COc1ccc(cc1)-c2c(C)c(nn2-c3ccc(Cl)cc3Cl)C(=O)NN4CCCCC4
• InChI: 1S/C23H24Cl2N4O2/c1-15-21(23(30)27-28-12-4-3-5-13-28)26-29(20-11-8-17(24)14-19(20)25)22(15)16-6-9-18(31-2)10-7-16/h6-11,14H,3-5,12-13H2,1-2H3,(H,27,30)
• InChIKey: KWDBQJRWPWTGPF-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

NIDA-41020 is a CB1 cannabinoid receptor antagonist. NIDA-41020 is structurally similar to Rimonabant, which is currently in clinical development. NIDA-41020 is less lipophilic; developed at NIDA as a potential radioligand for CB₁ receptors, K_i = 4.1 nM [in comparison AM 251, AM 281, SR 141716 (Rimonabant) have K_i of 0.6, 4.5 and 1.8 nM respectively].

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H300,H315,H319,H335
• P-Sätze: P261 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges