N4038

Anti-NAV3 (N-terminal) in Kaninchen hergestellte Antikörper

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(e): Anti-Neuron navigator 3, Anti-Pore membrane and/or filament interacting like protein 1 (POMFIL1), Anti-STEERIN3, Anti-human UNC-53 homolog (unc53H3)
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~280 kDa
• Speziesreaktivität: rat (predicted), human, mouse (predicted)
• Verpackung: antibody small pack of 25 μL
• Erweiterte Validierung: recombinant expression; Learn more about Antibody Enhanced Validation
• Konzentration: ~1 mg/mL
• Methode(n): western blot: 1-2 μg/mL using HEK-293T cells lysate expressing human NAV3 fusion protein
• UniProt-Hinterlegungsnummer: Q8IVL0
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... NAV3(89795) ; mouse ... Nav3(260315) ; rat ... Nav3(314814)

Beschreibung

Allgemeine Beschreibung

NAV3 (neuron navigator 3, also known as unc-53H3, steerin3, POMFIL1) belongs to the neuron navigator (NAV) family of proteins. NAV proteins are predominantly expressed in the nervous system. NAV3 expression is detected in brain.

NAV3 is made up of a calponin homology (CH) domain, a cytoskeletal interacting domain (CSID), four coiled-coil (CC) domains, and an AAA-domain.

Neuron navigator 3 (NAV3) is highly expressed in tumors. It possesses actin-binding domains and the gene encoding it is localized on chromosome 12q21.

Spezifität

Anti-NAV3 (N-terminal) specifically recognizes human NAV3.

Biochem./physiol. Wirkung

NAV3 (neuron navigator 3) has been suggested to function as a novel tumor suppressor gene. It is a putative haploin sufficient tumor suppressor gene, which helps in the growth, differentiation and apoptosis of cutaneous T-cell lymphoma (CTCL)cells.

NAV3 gene deletions and translocation affect patients with advanced mycosis fungoides or Sezary syndrome, the most common forms of primary cutaneous T-cell lymphoma (CTCL), suggesting that it may provide a novel diagnostic tool.

Neuron navigator 3 (NAV3) has been shown to control migration and invasion of epithelial cells. Once it is activated by growth factors, NAV3 occupies the ends of microtubules and stimulates their growth.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Lagerung und Haltbarkeit

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Haftungsausschluss

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)